Timeline: Tim Cook?s First Year As Apple CEO [One Year Of Tim]

It?s been a rocking year for Tim Cook, his first as Apple?s CEO. Not only didn?t he fuck up, Apple shipped a bunch of hit products and became the biggest company ever.

He also defused a big crisis in Apple?s Chinese supply chain and has made Apple a little more open and relaxed (just a teeny bit).

Hit the jump for a great timeline of what Apple?s been up to under Tim Cook?s tenure. (Really, it?s a fascinating timeline and was a ton of work).

Leander Kahney is the editor and publisher of Cult of Mac, and author of three books about technology culture: Inside Steve?s Brain, the New York Times bestseller about Steve Jobs; Cult of Mac; and Cult of iPod. Leander has written for Wired, MacWeek, Scientific American, and The Guardian in London. Follow Leander on Twitter @lkahney and Facebook.

(sorry, you need Javascript to see this e-mail address)| Read more posts by Leander Kahney.

Posted in News, Top stories | Tagged: Apple, ceo, one year of tim, Tim Cook, timeline |

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Source: http://www.cultofmac.com/186634/timeline-tim-cooks-first-year-as-apple-ceo-one-year-of-tim/

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globalEDGE Blog: South Korea Seeks to Harness its Tidal Power ...

As the international community continues to strive towards clean, renewable energy, South Korea has turned towards an abundant resource to power the future: the powerful waves of the Yellow Sea. Marine experts from Orkney, Scotland have recently agreed to advise South Korean engineers during the construction of a new tidal testing center in the northwestern Incheon Metropolitan City. The European Marine Energy Centre, or EMEC, has been operating in Scotland since 2003, where it has been developing technologies that generate electricity by harnessing the power of waves and tidal streams. Although the turbulent waves of the Yellow Sea have been noted as "very tough to work in," and EMEC spokeman has said that the waters offer some of the world's most tidal conditions, therefore making it a superb resource.

This project is not the first of its kind to reach South Korean shores, however. For eight years now, the South Korean government has been investing in and developing its tidal wave power plant infrastructure, including a fully-operating plant in Shihwa that began operations in 2011. The 254 megawatt Shihwa plant is also located off the Yellow Sea, and long-term feasibility studies have also been completed for planned sites, such as a 480 megawatt site projected to be at Garolim Bay. Building these new structures could potentially have a negative environmental impact, stated Keyyong Hong, director of marine structure and plant research at the Korea Ocean Research and Development Institute, so the building of research facilities to gather reliable data is an important first step before breaking ground.

South Korea's need to gather this information about marine technology was what brought EMEC to its shores, and displays the vital aspect that international collaboration has in the success of the global renewable energy industry. Moung Jo Cho, director general of economic hub promotion for Incheon, said that "the mutual benefits to be gained from this relationship are clear in terms of the support we can provide to one another." Aside from South Korea, EMEC has also been working on project through the Pacific region, including agreements with China's Ocean University, Japan's planned Marine Energy Center, and the planned Pacific Marine Energy Center of Oregon in the United States. As for the future of the renewable energy market, South Korean officials have reported that these developing projects have made the market worth $3.64 billion in 2012, and should be around $48 billion by 2022.

Source: http://globaledge.msu.edu/Blog/Post/1329/South-Korea-Seeks-to-Harness-its-Tidal-Power

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Older Fathers Pass On More Mutations To Children

Risks for autism and schizophrenia rise for kids of older fathers, and a new genetic study suggests why

By Ewen Callaway and Nature magazine

Older fathers? sperm have more mutations ? as do their children. Image: V. Pe?afiel/Flickr/GETTY

From Nature magazine

In the 1930s, the pioneering geneticist J. B. S. Haldane noticed a peculiar inheritance pattern in families with long histories of haemophilia. The faulty mutation responsible for the blood-clotting disorder tended to arise on the X?chromosomes that fathers passed to their daughters, rather than on those that mothers passed down. Haldane subsequently proposed¹ that children inherit more mutations from their fathers than their mothers, although he acknowledged that ?it is difficult to see how this could be proved or disproved for many years to come?.

That year has finally arrived: whole-genome sequencing of dozens of Icelandic families has at last provided the evidence that eluded Haldane. More?over, a study published in Nature findsthat the age at which a father sires children determines how many mutations those offspring inherit². By starting families in their thirties, forties and beyond, men could be increasing the chances that their children will develop autism, schizophrenia and other diseases often linked to new mutations. ?The older we are as fathers, the more likely we will pass on our mutations,? says lead author K?ri Stef?nsson, chief executive of deCODE Genetics in Reykjavik. ?The more mutations we pass on, the more likely that one of them is going to be deleterious.?

Haldane, working years before the structure of DNA was determined, was also correct about why fathers pass on more mutations. Sperm is continually being generated by dividing precursor cells, which acquire new mutations with each division. By contrast, women are born with their lifelong complement of egg cells.

Stef?nsson, whose company maintains genetic information on most Icelanders, compared the whole-genome sequences of 78?trios of a mother, father and child. The team searched for mutations in the child that were not present in either parent and that must therefore have arisen spontaneously in the egg, sperm or embryo. The paper reports the largest such study of nuclear families so far.

Fathers passed on nearly four times as many new mutations as mothers: on average, 55 versus 14. The father?s age also accounted for nearly all of the variation in the number of new mutations in a child?s genome, with the number of new mutations being passed on rising exponentially with paternal age. A 36-year-old will pass on twice as many mutations to his child as a man of 20, and a 70-year-old eight times as many, Stef?nsson?s team estimates.

The researchers estimate that an Icelandic child born in 2011 will harbour 70 new mutations, compared with 60 for a child born in 1980; the average age of fatherhood rose from 28 to 33 over that time.

Most such mutations are harmless, but Stef?nsson?s team identified some that studies have linked to conditions such as autism and schizophrenia. The study does not prove that older fathers are more likely than younger ones to pass on disease-associated or other deleterious genes, but that is the strong implication, Stef?nsson and other geneticists say.

Previous studies have shown that a child?s risk of being diagnosed with autism increases with the father?s age. And a trio of papers^3?5 published this year identified dozens of new mutations implicated in autism and found that the mutations were four times more likely to originate on the father?s side than the mother?s.

Source: http://rss.sciam.com/click.phdo?i=77de0a08a297a21c4e4cfb6deaf84f3e

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Understanding How Self Improvement Can Change ... - Total Vibration

It is often observed that heading down your journey of self-help can be quite a monotonous approach, but this is the case only if you don?t have the suitable information and facts to help you about the pursuit. This article gives you the data that you should get yourself started on your trip.

A lot of people have a problem with very low self esteem, it is really an on-going fight. To overcome these feelings, write scripts on your own and leave them in a variety of spots. For instance, you could potentially leave a take note for your self inside your auto which says ?I understand I will do a great job around the demonstration these days? or ?I realize more details on Task X than other people?. Optimistic strengthening is key to acquire rid of your negative feelings.

When you find yourself trying to better on your own, established a deadline. Select how extended you have got to make up your mind and stick with this time-body. The length of time do you need to reflect and collect information? When you choose, establish your due date and educate your self you are willing to reside a greater daily life.

If you want to create confidence in yourself, then you can definitely develop a personalized professional. This business must be a short dialog on the strong points and objectives. Any time you need a self-confidence improve you need to recite this professional before the vanity mirror outloud or in your thoughts should you like.

Boosting your social abilities will allow you to improve your self improvement. In case you have solid interactions which are solid and dependable, it will be easy to have access to more help. Your friends will likely be there to aid your learn more about on your own from your perspective that you simply don?t have.

Get plenty of sleep. A good night?s rest will not only fend off ailments, and often will also be sure that your thoughts are clean and prepared to the daily jobs that lay down before you. Failing to get sufficient sleep could make you stressed out and cranky, and it may virtually restrict everything you do. Don?t skimp around the attractiveness sleep at night.

Allow yourself communications filled up with optimistic imagery. Publish quotes and stating in spots exactly where you will observe them frequently. This helps to determine self speak that is ideal to your wellness. Consider utilizing your notebook computer, refrigerator, and restroom looking glass for placement of esteem creating communications. Rely on them to strengthen your belief in yourself.

Centering on one or more of such personal development strategies is a superb method for customers to boost their life. Any individual stuck within a rut and dissatisfied with the condition of their lifestyle would be wise to use these tips assiduously. Why wait around anymore to become anyone you?ve always aspired to be?

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Source: http://blog.thorsrubberhammer.com/2012/08/understanding-how-self-improvement-can-change-your-lifestyle/

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Mo. lawmaker still defiant, won't quit Senate race

FILE - This Aug. 10, 2012 file photo shows Todd Akin, Republican candidate for U.S. Senator from Missouri taking questions after speaking at the Missouri Farm Bureau candidate interview and endorsement meeting in Jefferson City, Mo. Akin fought to salvage his Senate campaign Monday, Aug. 20, 2012, even as members of his own party turned against him and a key source of campaign funding was cut off in outrage over the Missouri congressman's comments that women are able to prevent pregnancies in cases of "legitimate rape." (AP Photo/St. Louis Pos-Dispatch, Christian Gooden)

FILE - This Aug. 10, 2012 file photo shows Todd Akin, Republican candidate for U.S. Senator from Missouri taking questions after speaking at the Missouri Farm Bureau candidate interview and endorsement meeting in Jefferson City, Mo. Akin fought to salvage his Senate campaign Monday, Aug. 20, 2012, even as members of his own party turned against him and a key source of campaign funding was cut off in outrage over the Missouri congressman's comments that women are able to prevent pregnancies in cases of "legitimate rape." (AP Photo/St. Louis Pos-Dispatch, Christian Gooden)

Alaina Carnan of Lexington, Ky., works in the Senate campaign office of U.S. Rep. Todd Akin, R-Mo., Tuesday, Aug. 21, 2012 in Chesterfield, Mo. Akin has come under pressure to abandon his Senate compaign after his comments that women's bodies can prevent pregnancies in cases of "legitimate rape". (AP Photo/Bill Boyce)

A campaign sign stands outside the Senate campaign office of U.S. Rep. Todd Akin, R-Mo., Tuesday, Aug. 21, 2012 in Chesterfield, Mo. Rep. Akin has come under pressure to abandon his Senate compaign after his comments that women's bodies can prevent pregnancies in cases of "legitimate rape". (AP Photo/Bill Boyce)

FILE - In this Feb 18, 2012 file photo, Senate candidate Rep. Todd Akin, R-Missouri, waves to the crowd while introduced at a senate candidate forum during a Republican conference in Kansas City, Mo. The two losing candidates in the Republican primary for Missouri's U.S. Senate seat are getting renewed attention after Akin's comments about rape on Sunday, Aug. 19, 2012. (AP Photo/Orlin Wagner, file)

JEFFERSON CITY, Mo. (AP) ? Rep. Todd Akin defied the nation's top Republicans and refused to abandon a Senate bid that has been hobbled by fallout over his comments that women's bodies can prevent pregnancies in cases of "legitimate rape."

Akin took his message to network TV morning shows and conservative talk radio shows, declaring GOP leaders were overreacting by insisting he give up his quest to unseat Democrat Sen. Claire McCaskill of Missouri, and to social media with appeals for donations on his Twitter feed claiming "liberal elites" are trying to push him out of the race.

"I misspoke one word in one sentence on one day, and all of a sudden, overnight, everybody decides, 'Well, Akin can't possibly win,'" he said on a national radio show Tuesday hosted by former Republican presidential candidate Mike Huckabee. "Well, I don't agree with that."

Akin predicted he would bounce back from the political crisis threatening his campaign, including a call from presumptive presidential nominee Mitt Romney to leave the race, and capture a seat that is pivotal to Republican hopes of regaining control of the Senate.

He confirmed that Republican vice presidential candidate Paul Ryan also called to ask him to drop out. But Akin reiterated his decision to stand his ground, saying he refused to be bullied.

"It's not right for party bosses to override" the voters of Missouri, Akin said in an interview on ABC's "Good Morning America" Wednesday. He said he told Ryan that he was thinking things over and that he wants to "do what's right," but that he's not abandoning his race

Nonetheless, he said he would comply with Republican National Committee Chair Reince Priebus's request that he not attend the convention, which starts Monday.

But his bid faces tall obstacles ? chief among them a lack of money and party support.

In a potential sign of his strategy, Akin appealed Tuesday to Christian evangelicals, anti-abortion activists and anti-establishment Republicans. He said he remains the best messenger to highlight respect for life and liberty that he contends are crumbling under the policies of President Barack Obama.

In a new fundraising appeal Wednesday, Akin asserted "the liberal elite" are trying to "keep a strong, pro-life conservative out of the U.S. Senate." The email seeking $5 contributions also criticized his own party establishment, saying: "I have learned that many in the political class will duck and run for cover when faced with the slightest bit of adversity."

If he stays on the ballot, Akin will have to rebuild without any money from the national party and with new misgivings among rank-and-file Republican voters who just two weeks ago propelled him to a comfortable victory in a hotly contested three-way primary.

"I'm in this race for the long haul, and we're going to win it," he told radio host Dana Loesch in St. Louis.

Akin appealed to evangelicals directly during his interview with Huckabee, making allusions to the 9/11 terrorist attacks and focusing on the idea he had only misplaced a single word during a Sunday interview with St. Louis television station KTVI.

But Akin has been roundly criticized both for using the words "legitimate rape" and saying a woman's body has the ability to prevent conception after such an attack.

Hours earlier, Akin posted an online video in which he apologized again for his remarks. Campaign spokesman Ryan Hite said the apology was intended to cover the reference to "legitimate rape" and Akin's assertion that rape victims have a natural defense against pregnancy. The video will run as a 30-second ad on TV stations statewide for several days, Hite said.

Tuesday was the final day in which Akin could withdraw from the race without a court order. As the 5 p.m. deadline to withdraw neared, Republican leaders intensified their pressure on Akin to exit.

Sen. Roy Blunt issued a joint statement Tuesday with all four of Missouri's living former Republican senators ? John Ashcroft, Kit Bond, Jim Talent and John Danforth ? saying "it serves the national interest" for Akin to step aside.

Pointing to the group, Romney said the congressman should "accept their counsel."

A Romney aide said the candidate had been inclined to let Akin make the decision on his own. But after the Missouri lawmakers called for Akin to go, Romney wanted to make his position clear, said the aide, who requested anonymity because the aide was not authorized to publicly discuss Romney's thinking.

Akin provoked the political uproar when he was asked in the KTVI interview whether his general opposition to abortion extends to women who have been raped.

"It seems to me, first of all, from what I understand from doctors, that's really rare. If it's a legitimate rape, the female body has ways to try to shut that whole thing down," Akin said.

It's not clear if Akin's campaign will have the financial support to wage a prolonged advertising battle against McCaskill in the expensive St. Louis and Kansas City markets and the Republican-rich area of southwest Missouri.

The campaign arm of the Senate Republicans has already withdrawn $5 million in advertising planned for the Missouri race. The Karl Rove-backed Crossroads organization pulled its ads too. A fundraiser planned in Washington for next month was called off after all of the dozen GOP senators who had agreed to participate pulled out.

Crossroads President and CEO Steven Law suggested Tuesday that Akin was potentially helping Democrats retain their Senate majority by remaining in the race.

"The stakes in this election are far bigger than any one individual," said Brian Walsh, a spokesman for the National Republican Senatorial Campaign Committee. By staying in the race, Akin "is putting at great risk many of the issues that he and others in the Republican Party are fighting for."

Without that financial backing, Akin will need the support of social conservatives, who have formed his political base through a 12-year congressional career.

Noreen McCann, who lives in the same suburban St. Louis area as Akin, said Tuesday that his rape comment hasn't weakened her support for him. McCann expressed frustration that Akin was being publicly flayed for his ill-chosen words while other Democrats ? specifically President Bill Clinton ? have survived scandals that included accusations of sexual impropriety and lies.

Akin "is a man of principle. I trust and respect his integrity and his commitment to defending American values," said McCann, who had passed out Akin fliers on primary election day. "I think he wants to defend all innocent human life. If he misspoke, or it was in the wrong context, that is not a major problem for me."

But other Missouri Republicans are second-guessing their support for Akin.

Steven and Carolyn Sipes, a pair of retired public school teachers who are GOP committee members in southwest Missouri's Christian County, both voted for Akin in the primary. Carolyn is now doing some soul-searching prayer about whether Akin remains the best choice. Her husband believes Republicans would have a better shot of unseating McCaskill without Akin.

"If he decides to stay in, I'll back him to the hilt," Steven Sipes said. But "I think it would be better probably if he did drop out at this point. He's getting a lot of negative publicity."

Akin's campaign released an open letter Tuesday from Jack Willke, former president of the U.S. National Right to Life Committee, stating he was "outraged at how quickly Republican leaders have deserted" Akin.

Akin "remains a strong and courageous pro-life leader ? and awkward wording in one sound bite doesn't negate that," Willke's statement said.

___

Associated Press writers Jim Salter in St. Louis and Henry C. Jackson in Washington contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-08-22-Missouri%20Senate-Rape%20Comments/id-e4b94dc64375492f85bba4bb4c01570f

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Feds: Armed Wash. man arrested Obama threats

FEDERAL WAY, Wash. (AP) ? Authorities have arrested a Washington state man and are sweeping his apartment complex for explosives after emailed threats were made against President Barack Obama.

Emily Langlie, a spokeswoman for the Seattle U.S. attorney's office, says the suspect was armed but was taken into custody without incident in the south suburb of Federal Way on Tuesday afternoon. He was scheduled to appear in federal court Wednesday.

The man's name was not immediately released. He has not been charged.

Langlie said the threats had been sent to a general government email address.

Source: http://news.yahoo.com/feds-armed-wash-man-arrested-obama-threats-023330016.html

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Gold Nanoparticles Could Treat Prostate Cancer with Fewer

Home > Press > Gold Nanoparticles Could Treat Prostate Cancer with Fewer Side Effects than Chemotherapy

Abstract:
Using a compound in tea that is attracted to prostate tumor cells, researchers at the University of Missouri have developed a radioactive gold nanoparticle that kills prostate tumors, without triggering common side effects of prostate cancer therapy. "When we combined the tea compound with radioactive gold nanoparticles, the tea compound helped deliver the nanoparticles to the site of the tumors and the nanoparticles destroyed the tumor cells very efficiently," explained Kattesh Katti, who led the study. Dr. Katti and his colleagues published their work in the Proceedings of the National Academy of Sciences.

Bethesda, MD | Posted on August 21st, 2012

Today, doctors often treat prostate cancer by injecting hundreds of radioactive seeds into the prostate. However, that treatment is not effective when treating an aggressive form of prostate cancer. The size of the seeds and their inability to deliver effective doses hampers their ability to stop this aggressive form of prostate cancer. Dr. Katti and his colleagues solved this problem by using radioactive gold nanoparticles that require one or two injections.

One key component to this research was the discovery that epigallocatechin gallate, a compound in tea, has a particular affinity for prostate cancer cells. The other key component was the discovery that gold nanoparticles of just the right size will stay inside tumors once they reach their target. Radioactive gold was used because of its short half-life - all of it is decayed within three weeks of administration, an optimal time period for this type of radiotherapy.

Tests in mice showed that nearly three-quarters of the nanoparticles remained trapped in the prostate gland after injection into the tumor. Four weeks after injection, the average reduction in tumor volume was approximately 80 percent. Based on the results of these initial tests, the investigators plan larger preclinical studies with an eye on testing this formulation in human clinical trials.

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About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today?s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

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View abstract - ?Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer.?

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Govt.-Legislation/Regulation/Funding/Policy

Polymer Nanoparticle Overcomes Anticancer Drug Resistance August 21st, 2012

Gold Nanorods Hitch Ride on Immune Cells that Target Breast Tumors August 21st, 2012

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Nanomedicine

Nanoparticle Enhances Anticancer Immune Therapy with a One-Two Punch August 21st, 2012

Polymer Nanoparticle Overcomes Anticancer Drug Resistance August 21st, 2012

Gold Nanorods Hitch Ride on Immune Cells that Target Breast Tumors August 21st, 2012

Lessons Learned in Creating Biomedical Nanoparticles for Human Use August 21st, 2012

Discoveries

Nanoparticle Enhances Anticancer Immune Therapy with a One-Two Punch August 21st, 2012

Polymer Nanoparticle Overcomes Anticancer Drug Resistance August 21st, 2012

Gold Nanorods Hitch Ride on Immune Cells that Target Breast Tumors August 21st, 2012

Lessons Learned in Creating Biomedical Nanoparticles for Human Use August 21st, 2012

Announcements

Polymer Nanoparticle Overcomes Anticancer Drug Resistance August 21st, 2012

Gold Nanorods Hitch Ride on Immune Cells that Target Breast Tumors August 21st, 2012

Lessons Learned in Creating Biomedical Nanoparticles for Human Use August 21st, 2012

Solar Innovation to Support 'Energiewende' August 21st, 2012

Source: http://www.nanotech-now.com/news.cgi?story_id=45810

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